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A new, and as of yet unpublished study, has raised increased concern about the relationship between rofecoxib (Vioxx), Mercks blockbuster COX-2 inhibitor, and cardiovascular events.
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Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE.
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Those patients undergoing decompression alone may postoperatively develop progression or the new appearance of olisthy, while those primarily fused rarely show further increase or a new onset of slip.
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Patients with sensory-predominant neuropathy should be tested for glucose tolerance and vitamin B12 concentration.
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Pregabalin appears to be a safe and effective alternative for the treatment of painful diabetic polyneuropathy.
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In this population, deficient nutritional status may contribute to its relatively high incidence of cerebral vein thrombosis.
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CT angiography has high sensitivity and high negative predictive value for carotid disease.
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These findings provide compelling evidence in favor of the amyloid cascade hypothesis, which suggests that amyloid beta leads to the development of hyperphosphorylated tau aggregates within neurons.
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